Inhibition of nicotine-induced behavioral tolerance by ascorbic acid in female mice

نویسندگان

  • A Noroozzadeh
  • AA Aliabadi
  • AA Barzegari
  • H Ghoshooni
  • H Sahraei
  • M Alghaci
چکیده مقاله:

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 mg/kg, i.p.) once daily for 12 days in order to induce tolerance. At 13th day, an effective dose of nicotine (1 mg/kg, i.p.) was administered to the mice and activity of the animals was recorded for 20 min in an activity monitoring system (30 x 30 x 20 cm). Different doses of ascorbic acid (1-1000 mg/kg, i.p.) were administered to the animals in two ways: first group; the animals received ascorbic acid at days 1-12 of the experiments 10 min before the administration of nicotine (development). Second groups received ascorbic acid only at 13th day of the experiments (Expression). The results showed that administration of nicotine (0.5 mg/kg, i.p.) for 12 days to the mice induced behavioral tolerance in the animals. Injection of ascorbic acid (1-1000 mg/kg, i.p.) inhibits the development of nicotine-induced behavioral tolerance in the female mice. Administration of ascorbic acid (1-1000 mg/kg, i.p.) was ineffective to alter the expression of behavioral tolerance induced by nicotine. In conclusion, administration of ascorbic acid may inhibit the development of nicotine-induced behavioral tolerance, but it is ineffective to inhibit the effect of the expression of nicotine-induced behavioral tolerance.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ascorbic acid inhibits nicotine-induced behavioral sensitization in male mice

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

متن کامل

Ascorbic acid inhibits nicotine-induced behavioral sensitization in male mice

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

متن کامل

Ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in female mice

Introduction: The influence of ascorbic acid on the nicotine-induced conditioned place preference (CPP) and behavioral sensitization was investigated in the present study. Methods: In a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. Different doses of a...

متن کامل

ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in female mice

introduction: the influence of ascorbic acid on the nicotine-induced conditioned place preference (cpp) and behavioral sensitization was investigated in the present study. methods: in a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. different doses of ascor...

متن کامل

The effect of ascorbic acid on the acquisition and expression of nicotine-induced CPP in mouse

Increased activity of mesolimbic dopaminergic system within ventral tegmental area (VTA) due to nicotine results in psychologic dependence. It has been argued that function of dopamine receptors could by affected by ascorbic acid (AA). Furthermore, AA can decrease the withdrawal syndrome signs in addicted animals and may postpone the development of nicotine dependence. In the present study, the...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره Volume 3  شماره Supplement 1

صفحات  31- 31

تاریخ انتشار 2010-11-20

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023